Naltrexone is an FDA-approved medication traditionally used to treat alcohol and opioid dependence. In smaller, carefully titrated doses, it is increasingly prescribed off-label to support weight loss, especially in people who struggle with food addiction, binge eating, or emotional eating.
Naltrexone works by blocking opioid receptors in the brain, reducing the rewarding effects of food and curbing cravings—especially for sugar, carbs, and late-night snacking.
It may be prescribed alone or combined with other medications such as bupropion (as in the branded combo Contrave®), metformin, or GLP-1 medications like semaglutide or tirzepatide.
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Patients prescribed naltrexone as part of a medically supervised weight loss plan may experience:
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No. Naltrexone is FDA-approved for alcohol and opioid use disorder. However, it is commonly prescribed off-label to support weight loss and reduce food cravings when deemed appropriate by a licensed provider.
Naltrexone blocks the brain’s reward system, reducing the pleasure response to food and helping control compulsive eating behaviors. It also influences appetite-regulating hormones like POMC, especially when combined with bupropion.
Contrave® is a branded combination of naltrexone and bupropion. Your provider may prescribe naltrexone as a standalone medication or as part of a custom combination, based on your unique needs.
It’s especially helpful for patients who struggle with:
The most common side effects are nausea, headache, dizziness, and fatigue—usually mild and short-lived. Your provider will adjust the dose slowly to reduce side effects.
Naltrexone is usually prescribed in low to moderate oral doses, taken once daily or in divided doses. It is often started at a low dose and gradually increased for better tolerance.
Yes. Naltrexone is commonly used with bupropion, metformin, or GLP-1 medications like semaglutide or tirzepatide for enhanced results. Your provider will create a custom combination if appropriate.
Naltrexone is an FDA-approved medication indicated for the treatment of alcohol dependence and opioid use disorder. It is not FDA-approved for weight loss, but is often prescribed off-label by licensed providers to support appetite regulation, food craving reduction, and weight management.
Off-label prescribing is a common and legal medical practice when the benefits outweigh the risks and when supported by clinical evidence.
Naltrexone is not a controlled substance, is not habit-forming, and does not produce a euphoric effect. It should not be used in individuals currently dependent on opioids, as it can cause sudden withdrawal symptoms.
Patients should disclose all current medications and substance use history before starting naltrexone. Common side effects may include nausea, headache, dizziness, or fatigue. Serious side effects are rare but can include liver enzyme elevation or allergic reactions.
Always follow your provider’s instructions, and report any side effects or concerns promptly. Review the full Medication Guide before starting treatment.
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